842
Tom 68 · nr 12 · 2012
increased inhibitory potential on prostaglandin E2 and leukotriene
B4 formation in vitro. Bioorg. Med. Chem. 2010, 18: 2809–2815.
22. Oh S.Y., Kim Y.H., Bae D.S., Um B.H., Pan C.H., Kim C.Y., Lee H.J.,
Lee J.K.: Anti-inflammatory effects of gomisin N, gomisin J, and schi-
sandrin C isolated from the fruit of Schisandra chinensis. Biosc. Bio-
technol. Biochem. 2010, 74(2): 285–291.
23. Wan C.K., Tse A.K., Yu Z.L., Zhu G.Y., Wang H., Fong D.W.: Inhibi-
tion of cytochrome P450 3A4 activity by schisandrol A and gomi-
sin A isolated from Fructus Schisandrae chinensis. Phytomedicine
2010, 17(8–9): 702–705.
24. Lu Y., Chen D-F.: Analysis of Schisandra chinensis and Schisandra
sphenanthera. J Chromatogr. A. 2009, 1216: 1980–1990.
25. Chen D.F., Zhang S.X., Kozuka M., Sun Q.Z., Feng J., Wang Q., Mu-
kainaka T., Nobukuni Y., Tokuda H., Nishino H., Wang H.K., Morris-
-Natschke S.L., Lee K.H.: Interiotherins C and D, two new lignans
from Kadsura interior and antitumor-promoting effects of related
neolignans on Epstein-Barr virus activation. J. Nat. Prod. 2002, 65:
1242–1245.
26. Fong W.F., Wan C.K., Zhu G.Y., Chattopadhyay A., Dey S., Zhao Z.Z.,
Shen X.L.: Schisandrol A from Schisandra chinensis Reverses P-Gly-
coprotein-Mediated Multidrug Resistance by Affecting Pgp-Substra-
te Complexes. Planta Med. 2007, 73: 212.
27. Li L., Lu Q., Shen Y., Hu X.: Schisandrin B enhances doxorubicin-in-
duced apoptosis of cancer cells but not normal cells. Biochem. Phar-
macol. 2006, 71: 584–595.
28. Fil’kin A.M.: About Schizandra chinensis (historical-literary infor-
mation). Aptechnojje Delo 1952, 2, 46–48.
29. Panossian A., Wikman G.: Pharmacology of Schisandra chinensis
Bail.: An overview of Russian research and uses in medicine. J. Eth-
nopharm. 2008, 118: 183–212.
30. Bensky D., Gamble A.: Chinese Herbal Medicine Materia Medica.
Eastland Press, 1993: 376–378.
31. Ko K.M., Mak D.H.F., Li P.C., Poon M.K.T., Ip S.P.: Enhancement
of hepatic glutathione regeneration capacity by a lignan-enriched
extract of Fructus Schisandrae in rats. Jap. J. Pharmacol. 1995, 69:
439–442.
32. Ko K.M., Ip S.P., Poon M.K.T., Wu S.S., Che C.T., Ng K.H., Kong Y.C.:
Effect of a lignan-enriched Fructus Schisandrae extract on hepatic
glutathione status in rats: protection against carbon tetrachloride to-
xicity. Planta Med. 1995, 61: 134–137.
33. Tiantong B., Gengtao L., Zhenyu S.: A comparison of the pharmaco-
logic actions of 7 constituents isolated from Fructus Schizandrae.
Chin. Med. J. 1980, 93: 41–47.
34. Lu H., Liu G.T.: Effect of dibenzo[a,c] cyclooctadiene lignans isolated
from Fructus Schizandrae on lipid peroxidation and anti-oxidative
enzyme activity. Chem. Biol. Interac. 1991, 78: 77–84.
35. Hancke J., Burgos R., Wikman G., Ewertz E., Ahumada F.: Schizan-
dra chinensis, a potential phytodrug for recovery of sport horses. Fi-
toterapia 1994, 65: 113–118.
36. Brekhman I.I., Dardymov I.V.: New substances of plant origin which
increase nonspecific resistance. Ann. Rev. Pharm. 1969, 9: 419–430.
37. Panossian A.G., Oganessian A.S., Ambartsumian M., Gabrielian E.S.,
Wagner H., Wikman G.: Effects of heavy physical exercise and ada-
ptogens on nitric oxide content in human saliva. Phytomedicine
1999, 6: 17–26.
38. Trusov M.S.: Schizandra chinensis effect on adaptation to darkness.
Materials for the study of ginseng and schizandra. Moscow 1958:
170–176.
39. Yasukawa K., Ikeya Y., Mitsuhashi H., Iwasaki M., Aburada M., Naka-
gawa S., Takeuchi M., Takido M.: Gomisin A inhibits tumor promo-
tion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carci-
nogenesis in mouse skin. Oncology 1992, 49: 68–71.
40. Lu H., Liu G.T.: Antioxidant activity of dibenzocyclooctadiene lignans
isolated from Schisandraceae. Planta Med. 1992, 58: 311–313.
41. Ip S.P., Ko K.M.: The crucial antioxidant action of schisandrin B
in protecting against carbon tetrachloride hepatotoxicity in mice:
a comparative study with butylated hydroxytoluene. Biochem. Phar-
macol. 1996, 52: 1687–1693.
42. Mak D.H., Ip S-P., Li P-C., Poon M.K.: Effects of schisandrin B and al-
pha-tocopherol on lipid peroxidation, in vitro and in vivo. Mol. Cell
Biochem. 1996, 165: 161–165.
43. Ip S.P., Mak D.H., Li P.C., Poon M.K., Ko K.M.: Effect of a lignan-en-
riched extract of Schisandra chinensis on aflatoxin B1 and cadmium
chloride-induced hepatotoxicity in rats. Pharmacol. Toxicol. 1996,
78(6): 413–416.
44. Ohtaki Y., Nomura M., Hida T., Miyamoto K., Kanitani M., Aizawa T.,
Aburada M.: Inhibition by gomisin A, a lignan compound, of hepa-
tocarcinogenesis by 3’-methyl-4-dimethylaminoazobenzene in rats.
Biol. Pharm. Bullet. 1994, 17: 808–814.
45. Yim S.Y., Lee Y.J., Lee Y.K., Jung S.E., Kim J.H., Kim H.J., Son B.G.,
Park Y.H., Lee Y.G., Choi Y.W., Hwang D.Y.: Gomisin N isolated from
Schisandra chinensis significantly induces anti-proliferative and
pro-apoptotic effects in hepatic carcinoma. Mol. Med. Rep. 2009,
2(5): 725–732.
46. Miao M.S., Gao J.L., Zhang G.W., Ma X., Zhang Y.: Effect of Schisan-
dra chinensis polysaccharide on intracerebral acetylcholinesterase
and monoamine neurotransmitters in a D-galactose-induced aging
brain mouse model. Neural. Regen. Res. 2009, 4: 687–693.
47. Winston D., Maimes S.: Adaptogens: Herbs for Strength, Stamina, and
Stress Relief. Rochester, Vermont: Healing Arts Press 2007.
48. Gopaul R., Kern D.G., Knaggs H.E., Lephart J.F.: Narcissus tazetta
and Schizandra chinensis to Regulate ‘Youth Gene Clusters’ – An In
vitro Analysis. Cosm. Toil. 2012: 446–448.
49. Lee H.J., Kim C.Y.: Simultaneous determination of nine lignans using
pressurized liquid extraction and HPLC – DAD in the fruits of Schi-
zandra chinensis. Food Chem. 2010, 120: 1224–1228.
50. Szopa A., Ekiert H.: Lignans in Schisandra chinensis in vitro cultu-
res. Pharmazie. 2011, 66: 633–634.
51. Zhang H., Zhang G., Zhu Z., Zhao L., Fei Y., Jing J., Chai Y.: Determi-
nation of six lignans in Schisandra chinensis (Turcz.) Baill. fruits and
related Chinese multiherb remedies by HPLC. Food Chem. 2009, 115:
735–739.
52. Avula B., Choi Y-W., Srinivas P.V., Khan I.A.: Quantitative Determi-
nation of Lignan Constituents from Schisandra chinensis by Liquid
Chromatography. Chromatographia 2005, 61: 515–518.
53. Halstead C.W., Lee S., Khoo C.S., Hennell J.R., Bensoussan A.: Vali-
dation of a method for the simultaneous determination of four Schi-
sandra lignans in the raw herb and commercial dried aques extracts
of Schisandra chinensis (Wu Wei Zi) by RP – LC with DAD. J. Pharm.
Biomed. Anal. 2007, 45: 30–37.
54. Kim H.J., Jee E.H., Ahn K.S., Choi H.S., Jang Y.P.: Identification of
Marker Compounds in Herbal Drugs on TLC with DART – MS. Arch.
Pharm. Res. 2010, 9: 1355–1359.
55. Kim H.J., Oh M.S., Hong J., Jang Y.P.: Quantitative Analysis of Major
Dibenzocyclooctane Lignans in Schisandrae Fructus by On-line TLC
– DART – MS. Phytochem. Anal. 2011, 22: 258–262.
56. Ohno T., Mikami E., Oka H.: Analysis of crude drugs using reversed
– phase TLC/scanning densitometry. (II) Identification of ginseng,
red ginseng, gentian, Japanese gentian, pueraria root, gardenia fru-
it, schisandra fruit and ginger. J. Nat. Med. 2006, 60: 141–145.
57. Wang K., Song W., Tong Y.: Identification of Schisandra by TLC – den-
sitometry. China J. Chin. Materia Med. 1991, 125: 70–71.
58. Wangt K., Tong Y.Y., Song W.Z.: Determination of the active ingre-
dients in Chinese drug wuweizi (Schisandra chinensis) by TLC – den-
sitometry. Acta Pharm. Sin. 1990, 25: 49–53.
59. Opletal L., Sovova H., Bartlova M.: Dibenzo[a,c]cyclooctadiene li-
gnans of the genus Schisandra: importance, isolation and determi-
nation. J. Chromatogr. B. 2004, 812: 357–371.
60. Lu Y., Chen D.: Analysis of Schisandra chinensis and Schisandra
sphenanthera. J. Chromatogr. A. 2009, 1216: 1980–1990.
61. Schwarzinger C., Kranawetter H.: Analysis of the Active Compounds
in Different Parts of the Schisandra chinensis Plant by Means of Py-
rolysis – GC/MS. Monatshefte fűr Chemie 2004, 135: 1201–1208.
62. Kvasničková L., Glatz Z., Štĕbová H., Kahle V., Slanina J., Musil P.: Ap-
plication of capillary electrochromatography using macroporous po-
lyacrylamide columns for the analysis of lignans from seeds of Schi-
sandra chinensis. J. Chromatogr. A. 2001, 916: 265–271.
63. Tian K., Qi S., Cheng Y., Chen X., Hu Z.: Separation and determination
of lignans from seeds of Schisandra species by micellar electrokine-
tic capillary chromatography using ionic liquid as modifier. J. Chro-
matogr. A. 2005, 1078: 181–187.
64. Zhang L.Q., Zhang X.P., Zhao L.M.: Simultaneous Determination of
3 Active Components in the Ready – Made Chinese Drug Schisandra
chinensis Compound by Target Factor – Spectrophotometry. Lihua
Jianyan, Huaxue Fence. 2007, 43: 264.
65. Dzik E.: Analiza zawartości lignanów w przetworach cytryńca
chińskiego techniką wysokosprawnej chromatografii cienkowar-
stwowej. Praca magisterska, Wydział Farmaceutyczny UJ CM, 2012.
66. Ekiert R., Szopa A., Ekiert H., Krzek J., Dzik E.: Analysis of li-
gnans in Schisandra chinensis preparations and in vitro cultures
using HPTLC-densitometry. Biomed. Chromatogr. – submitted for
publication.
67. Ekiert H.: Farmaceutyczne aspekty biotechnologii roślin. Część I.
Wprowadzenie, metodyka i główne kierunki badawcze. Farm. Pol.
2009, 65: 69–77.
68. Smíšková A., Vlašínová H., Havel I.: Somatic embryogenesis from
zygotic embryos of Schisandra chinensis. Biol. Plant. 2005, 49,
451-454.
69. Yang J.L., Da Niu Y., Yang C.P., Liu G.F., Li C.H.: Induction of somatic
embryogenesis from female flower buds of elite Schisandra chinen-
sis. Plant Cell. Tiss. Organ Cult. 2011, 106(3): 391–399.
70. Kim T.D., Anbazhagan Ramesh V., Park J.I.: Somatic embryogenesis
in Schisandra chinensis (Turcz.) Baill. In Vitro Cell Dev. Biol.-Plant.
2005, 41: 253–257.